Sr. Scientist, In Vivo CAR-T
Company: Legend Biotech
Location: Philadelphia
Posted on: December 1, 2025
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Job Description:
Legend Biotech is a global biotechnology company dedicated to
treating, and one day curing, life-threatening diseases.
Headquartered in Somerset, New Jersey, we are developing advanced
cell therapies across a diverse array of technology platforms,
including autologous and allogenic chimeric antigen receptor
T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based
immunotherapy. From our three R&D sites around the world, we
apply these innovative technologies to pursue the discovery of
safe, efficacious and cutting-edge therapeutics for patients
worldwide. Legend Biotech entered into a global collaboration
agreement with Janssen, one of the pharmaceutical companies of
Johnson & Johnson, to jointly develop and commercialize
ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is
designed to combine the strengths and expertise of both companies
to advance the promise of an immunotherapy in the treatment of
multiple myeloma. Legend Biotech is seeking a Sr. Scientist, In
Vivo CAR-T as part of the R&D team based in Philadelphia, PA.
Role Overview Legend Biotechnology is a leader in the development
of cutting-edge cell-based therapies. We are seeking a highly
motivated and experienced Senior Scientist to join our rapidly
expanding in vivo CAR-T cell therapy team. This role offers the
opportunity to contribute directly to the advancement of our in
vivo CAR-T platform and pipeline. The ideal candidate will bring
deep expertise in cellular immunotherapy and a strong foundation in
virology and immunology. You will collaborate across research,
development, and manufacturing teams to translate preclinical
discoveries into impactful clinical applications. Your scientific
insight and collaborative spirit will be essential in driving
innovation and improving patient outcomes. Key technical
competencies include lentivirus preparation and execution of ex
vivo and in vitro functional assays to assess product potency and
safety. The successful candidate will demonstrate scientific rigor,
integrity, and the ability to deliver results within timelines,
while fostering a culture of teamwork and excellence in a
fast-paced environment. Key Responsibilities Lead, design and
execute research to develop cell and gene therapy platforms.
Optimize cell-based immunoassays, including immune cell isolation
and expansion, T cell culture, virus packaging and titering,
multi-color flow cytometry, ELISA, cell-based cytotoxic assays, PCR
analysis. Work closely with team to test different designs to
deliver reliable and consistent data. Document and interpret
scientific results, present the data within research team and
cross-functional teams. Requirements PhD in Immunology, cell
biology or related discipline. 4 years of experience in the field
of cell therapy, in vivo CAR-T experience preferred. Track record
of productivity evidenced by publications and/or patents.
Experience in supporting projects from early research to clinical
stage is a plus. Excellent verbal and written communication skills.
Stay alert to industry development, keep learning and be
comfortable in a fast-paced team. Li-JR1 Li-Onsite The anticipated
base pay range is $123,605 - $162,232 USD Benefits We are committed
to creating a workplace where employees can thrive - both
professionally and personally. To attract and retain top talent in
a highly competitive industry, we offer a best-in-class benefits
package that supports well-being, financial stability, and
long-term career growth. Our offerings are designed to meet the
diverse needs of our team members and their families, ensuring they
feel valued and supported every step of the way. Highlights include
medical, dental, and vision insurance as well as a
401(k)-retirement plan with company match that vest fully on day
one. Equity and stock options are available to employees in
eligible roles, we offer eight weeks of paid parental leave after
just three months of employment, and a paid time off policy that
includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S.
national holidays, and 3 floating holidays. Additional benefits
include flexible spending and health savings accounts, life and
AD&D insurance, short- and long-term disability coverage, legal
assistance, and supplemental plans such as pet, critical illness,
accident, and hospital indemnity insurance. We also provide
commuter benefits, family planning and care resources, well-being
initiatives, and peer-to-peer recognition programs - demonstrating
our ongoing commitment to building a culture where our people feel
empowered, supported, and inspired to do their best work. EEO
Statement Legend Biotech is a proud equal opportunity/affirmative
action employer committed to attracting, retaining, and maximizing
the performance of a diverse and inclusive workforce. It is
Legend’s policy to ensure equal employment opportunity without
discrimination or harassment based on race, color, religion, sex
(including pregnancy, childbirth, or related medical conditions),
sexual orientation, gender identity or expression, age, disability,
national origin, marital or domestic/civil partnership status,
genetic information, citizenship status, uniformed service member
or veteran status, or any other characteristic protected by
applicable law. Employment is at-will and may be terminated at any
time with or without cause or notice by the employee or the
company. Legend may adjust base salary or other discretionary
compensation at any time based on individual, team, performance, or
market conditions. Legend Biotech maintains a drug-free
workplace.
Keywords: Legend Biotech, Philadelphia , Sr. Scientist, In Vivo CAR-T, Science, Research & Development , Philadelphia, Pennsylvania
