Scientist II

Company: Legend Biotech
Location: Philadelphia
Posted on: November 4, 2025

Job Description:

Legend Biotech is a global biotechnology company dedicated to treating, and one day curing, life-threatening diseases. Headquartered in Somerset, New Jersey, we are developing advanced cell therapies across a diverse array of technology platforms, including autologous and allogenic chimeric antigen receptor T-cell, T-cell receptor (TCR-T), and natural killer (NK) cell-based immunotherapy. From our three R&D sites around the world, we apply these innovative technologies to pursue the discovery of safe, efficacious and cutting-edge therapeutics for patients worldwide. Legend Biotech entered into a global collaboration agreement with Janssen, one of the pharmaceutical companies of Johnson & Johnson, to jointly develop and commercialize ciltacabtagene autolecuel (cilta-cel). Our strategic partnership is designed to combine the strengths and expertise of both companies to advance the promise of an immunotherapy in the treatment of multiple myeloma. Legend Biotech is seeking a Scientist II as part of the R&D Novel Car Design team based in Philadelphia, PA. Role Overview We are seeking a highly motivated and creative scientist to grow our pipeline efforts. The successful candidate will be part of Legend Biotech, a leading cell therapy company with commercial CAR drug product CARVYKTI and an attractive pipeline portfolio. The candidate will be an integral part of our R&D team, whose aim is to research, develop and advance the next generation of cell therapies using cutting edge in vivo gene delivery technologies and create innovative novel CAR designs for a wide range of human indications. This position will focus on in-vivo CAR. The position requires enthusiasm, passion, outstanding skills in the art, attention to detail, and a desire to create new medicines for patients. Key Responsibilities Be able to work independently under minimal supervision. Lead, design and optimize research with aims of exploring next generation cell therapies using in-vivo CAR virus Perform functional characterization of T cells transduced with in-vivo CAR virus using multiple functional assays but not limited to cytotoxicity assay, serial cytotoxicity assay, and cytokine release assay etc. Help execute the evaluation of in-vivo CAR virus using in-vitro assays and in-vivo mice models. Design, execute and interpret research requiring molecular biology techniques including PCR/DDPCR/ qPCR, NGS, RNA and DNA analysis. Perform research requiring cell biology techniques including cell culture, transfection, FACS, and cellbased assays. Analyze and present data to a wide range of audiences of internal group meetings and other forums. Dissect published literature to find novel solutions to in-vivo cell therapy problems. Generate, manage, evaluate, and maintain critical data in a highly organized manner. Requirements PhD in Biology or related discipline 3 years of experience in the field of cell therapy with cell culture methods (T cells, CAR-T or TCR-T preferred), quantitative PCR and functional characterization of T cells (Cytotoxicity assay using Incucyte or xCelligence, and MLR assay). Prior experience with in-vivo CAR virus evaluation will be preferred. Proficient in cell-based assays with various read out technologies such as flowcytometer, Incucyte, Xcelligence. Experience with transfection and lentivirus or retrovirus transduction. Experience/ working knowledge (molecular biology and cellular biology) in design and evaluation of modified viruses. Individual should be go-getter and be able to work independently. Excellent written and oral communication skills. Li-JR1 Li-Hybrid The anticipated base pay range is $107,482 - $141,070 USD Benefits We are committed to creating a workplace where employees can thrive - both professionally and personally. To attract and retain top talent in a highly competitive industry, we offer a best-in-class benefits package that supports well-being, financial stability, and long-term career growth. Our offerings are designed to meet the diverse needs of our team members and their families, ensuring they feel valued and supported every step of the way. Highlights include medical, dental, and vision insurance as well as a 401(k)-retirement plan with company match that vest fully on day one. Equity and stock options are available to employees in eligible roles, we offer eight weeks of paid parental leave after just three months of employment, and a paid time off policy that includes 15 vacation days, 5 personal days, 5 sick days, 11 U.S. national holidays, and 3 floating holidays. Additional benefits include flexible spending and health savings accounts, life and AD&D insurance, short- and long-term disability coverage, legal assistance, and supplemental plans such as pet, critical illness, accident, and hospital indemnity insurance. We also provide commuter benefits, family planning and care resources, well-being initiatives, and peer-to-peer recognition programs - demonstrating our ongoing commitment to building a culture where our people feel empowered, supported, and inspired to do their best work. EEO Statement Legend Biotech is a proud equal opportunity/affirmative action employer committed to attracting, retaining, and maximizing the performance of a diverse and inclusive workforce. It is Legend’s policy to ensure equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, uniformed service member or veteran status, or any other characteristic protected by applicable law. Employment is at-will and may be terminated at any time with or without cause or notice by the employee or the company. Legend may adjust base salary or other discretionary compensation at any time based on individual, team, performance, or market conditions. Legend Biotech maintains a drug-free workplace.

Keywords: Legend Biotech, Philadelphia , Scientist II, Science, Research & Development , Philadelphia, Pennsylvania