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Upstream Process Development Scientist

Company: Actalent
Location: Philadelphia
Posted on: November 26, 2022

Job Description:


  • Reporting to the Associate Director of Vector Process Development, the Upstream Process Development Scientist will work in close collaboration with colleagues in Downstream Process Development, Analytical Development, Discovery, Clinical, Manufacturing, and other areas. They will be responsible for executing cell culture activities in both adherent and suspension platforms and assist in the development of efficient, robust and scalable viral vector production processes. The successful candidate will be also responsible for working with members of cross-functional teams in support of contract development and manufacturing organizations.Responsibilities:
    • Execute and support laboratory studies for the development, optimization, and manufacturing of viral vectors with minimal supervision.
    • Maintenance, expansion, and banking of both adherent and suspension cell cultures.
    • Execute and support analytical methods for process development studies.
    • Write, maintain, and review laboratory notebooks and logbooks.
    • Prepare and deliver presentations at team and company meetings.
    • Participate in a cross-functional team to transfer technology to cGMP manufacturing partners.
    • Interact with internal cross-functional team members including Manufacturing, Nonclinical, Clinical, QA, Regulatory, Legal, and Research.
    • Work effectively in a team environment to meet project timeline and objectives.Skills & Qualifications:
      • Bachelor of Science degree with at least 2+ years of hands-on experience.
      • Biotechnology industry experience in cGMP manufacturing, process development, or research and discovery.
      • Experience with one or more of the following:
        • Closed system assembly use and design
        • Shake flask, bioreactor, and/or adherent mammalian cell culture technologies
        • Viral transduction/transfection or expression systems
        • Primary cell isolation and culture
        • Experience performing analytical methods such as ELISA, qPCR/ddPCR and flow cytometry.
        • Experience in adherent/suspension mammalian cell culture, virus production, and/or viral infection assays.
        • Experience maintaining written records of work in the form of laboratory notebooks (paper or electronic).
        • Proficiency with Microsoft Excel or statistical analysis software (JMP, Minitab, Prism, etc.) for analyzing and presenting data. About Actalent: Actalent connects passion with purpose. Our scalable talent solutions and services capabilities drive value and results and provide the expertise to help our customers achieve more. Every day, our experts around the globe are making an impact. We're supporting critical initiatives in engineering and sciences that advance how companies serve the world. Actalent promotes consultant care and engagement through experiences that enable continuous development. Our people are the difference. Actalent is an operating company of Allegis Group, the global leader in talent solutions. The company is an equal opportunity employer and will consider all applications without regards to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.

Keywords: Actalent, Philadelphia , Upstream Process Development Scientist, Other , Philadelphia, Pennsylvania

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