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Senior Scientist, Biochemistry, Enzymology, Biophysics - Springhouse, PA.

Company: Johnson & Johnson
Location: Spring House
Posted on: January 16, 2022

Job Description:

Janssen Research & Development, L.L.C., a Johnson & Johnson company, is recruiting for a Senior Scientist, Biochemistry, Enzymology, Biophysics for the Molecular and Cellular Pharmacology team, located in Spring House, PA.

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.

We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

Janssen has formed a global multidisciplinary Targeted Protein Degradation group across all five Janssen Therapeutic Area (TA) discovery teams. The TPD group mission requires deep scientific expertise in various disciplines including biochemistry, enzymology, biophysics, molecular and cellular pharmacology, and screening technologies coupled with an ability to work collaboratively with internal and external partners. Building on a strong legacy of success, we are currently seeking an outstanding enzymologist/biochemist/biophysicist to join our team as a Senior Scientist, Biochemistry, Enzymology, Biophysics.

The candidate will be a key member of the Targeted Protein Degradation team within the Molecular and Cellular Pharmacology group at Janssen, and provide biochemistry/enzymology/biophysics support and expertise to therapeutic area programs from target nomination through declaration of a clinical candidate. S/he should be an agile learner and innovative problem solver who is capable of multi-tasking in a fast paced and collaborative environment.

In This Exciting Role, You Will
Employ a combination of scientific tools and methodologies in mechanistic biochemistry/enzymology/biophysics including reagent validation, binding and activity assay development, ligand-target mechanism of action studies, and compound profiling.
Develop and execute target relevant, fit for purpose biochemical/biophysical/enzymatic assays to support hit triage and progression of candidate quality molecules
Provide enzymology/biophysics expertise to internal programs as well as external collaborations.
Explore novel technologies
Collaborate across multiple therapeutic teams and functional areas in the US, Europe and Asia.
Provide a sense of urgency to deliver data within agreed timelines
Publish research in high-quality journals

PhD is required
Postdoctoral experience is preferred
At least 3 or more years of industry related experience in enzymology/biochemistry/biophysics/pharmacology or related is required.
Proven experience and knowledge in biochemistry, enzymology, assay development, and/or mechanism of action studies is required
Expertise in enzymology with a proven track record of using steady-state, pre-steady state, and mechanism of action studies to fully characterize target-ligand interactions is preferred
Strong background in biophysics, protein biochemistry, and assay development is required
Hands-on experience in direct binding studies like SPR, ITC, or MST is preferred
Excellent analytical skills and the ability to analyze and interpret complex data sets is required
Experience in leading projects independently is preferred
Experience in HTS and automation is preferred
Cellular assay experience is preferred

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.

Primary Location

United States-Pennsylvania-Spring House-Welsh & McKean Roads


Janssen Research & Development, LLC (6084)

Job Function


Requisition ID


Keywords: Johnson & Johnson, Philadelphia , Senior Scientist, Biochemistry, Enzymology, Biophysics - Springhouse, PA., Other , Spring House, Pennsylvania

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