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Senior Scientist - Cheminformatics - Spring House, PA - (Multiple Openings).

Company: Johnson & Johnson
Location: Spring House
Posted on: January 16, 2022

Job Description:

Janssen Research & Development, L.L.C., a division of Johnson & Johnson's Family of Companies, is recruiting for a Senior Scientist, Cheminformatics located in Spring House, PA (Philadelphia area).

At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science.

We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at and follow us @JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies.

The Discovery Sciences organization within Janssen R&D is continuing to build key scientific expertise in screening, pharmacology and chemistry to partner closely with therapeutic area scientists to develop groundbreaking new medicines in the areas of Oncology, Immunology, Neuroscience, Cardiovascular, and Infectious Diseases. We are seeking excellent drug discovery scientists to join the team to bring their expertise to exciting efforts in novel areas of drug discovery.

We are seeking a creative individual with a strong background in cheminformatics and data science to join the Computational Chemistry group at Janssen. This person will be responsible for exploration in a broad range of cheminformatics areas, including automation integration, high throughput experimentation (HTE) and DNA-encoded library (DEL) data capture and interpretation, peptide discovery platform informatics, and high-throughput screening data analysis.

As a Senior Scientist in the Computational Chemistry group, you will:
Enable compound design, synthesis, purification, data analysis, visualization and decision support for parallel synthesis, high throughput experimentation (HTE), DNA-encoded library (DEL) synthesis and screening, and affinity selection (ASMS).
Annotate and assess the success rates of screening platforms and compound collections.
Closely collaborate with other teams within Janssen, including computational chemists, ML/AI scientists, IT, medicinal chemists, and focused chemistry and biology discovery technology groups.
Develop multidimensional data visualizations to allow interpretation and structure of complex data from multiple internal and external sources into a format usable by project teams.

PhD in chemistry, computer science, or a related field and at least 3 years of pharmaceutical industry experience is required, or a MS degree in chemistry, computer science, or a related field with at least 14 years of pharmaceutical industry experience is required
Extensive hands-on experience in cheminformatics (ie. chemical descriptors, similarity, diversity, SAR analysis, properties, library enumeration, design, chemical transformations, etc.) with proven track record of accomplishments is required.
Proficiency with one or more programming, scripting, or querying languages is required. Examples may include Python, Jupyter Notebooks, Java, Pipeline Pilot, or SQL.
Expertise in large scale data handling is preferred.
Expertise in generating data visualizations in tools like Spotfire, Vortex, Tableau, DataWarrior is preferred.
Familiarity with computational chemistry approaches such as molecular modelling, docking, pharmacophore analysis is preferred.
Excellent written and oral communication skills are required.
This position is located in Spring House, PA (Philadelphia area) and may require approximately 10% travel.

Johnson & Johnson is an Affirmative Action and Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, or protected veteran status and will not be discriminated against on the basis of disability.


Primary Location

United States-Pennsylvania-Spring House-Welsh & McKean Roads


Janssen Research & Development, LLC (6084)

Job Function


Requisition ID


Keywords: Johnson & Johnson, Philadelphia , Senior Scientist - Cheminformatics - Spring House, PA - (Multiple Openings)., Other , Spring House, Pennsylvania

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