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Scientific Leader, PBPK Modeling

Company: GlaxoSmithKline
Location: Collegeville
Posted on: June 12, 2021

Job Description:

Site Name: UK - Hertfordshire - Stevenage, USA - Pennsylvania - Upper Providence Posted Date: Jun 4 2021 GSK is looking for a dynamic scientist to join their PBPK modeling team in the DMPK modeling group. The PBPK scientist will have the opportunity to lead PBPK projects with end to end applications of their modeling efforts from early discovery to late stage drug development. Along with other DMPK team members, this scientist will collaborate across various cross-functional teams such as toxicology, biology, chemistry, clinical pharmacology and formulations and will contribute to the prediction of human pharmacokinetics to support candidate nomination, assess drug interactions and contribute to internal dossiers & regulatory responses. Key Responsibilities: Primarily to apply PBPK models for pre-clinical and clinical PK predictions, tissue distribution and human dose prediction. Independently build and validate PBPK models to support evaluation of absorption and systemic exposure potential for new chemical entities Apply PBPK platforms as per the regulatory expectations to address DDI as well as PK predictions in special populations (e.g. patients, organ impairment). Provide valuable inputs to various in vitro DMPK assays as well as clinical study protocols based on modeling outputs or requirements. Provide valuable training and mentoring to existing and new staff Present modeling outputs in internal department meetings as well as external /international conferences. Why you? Basic qualifications: PhD in a relevant scientific discipline (Maths, pharmacology, biochemistry or other DMPK related science) with 5 years of experience. Experience with PBPK software SimCYP and /or Gastroplus. Preferred qualifications: Successful track record of applying PBPK into projects Knowledge of DMPK processes in drug discovery and development. Understanding of the in vitro/ in vivo experiments used to describe general ADME principles especially drug absorption and drug distribution. Scientific writing and presentation ability with excellent verbal communication skills. Why GSK? Our values and expectations are at the heart of everything we do and form an important part of our culture. These include Patient focus, Transparency, Respect, Integrity along with Courage, Accountability, Development, and Teamwork. As GSK focuses on our values and expectations and a culture of innovation, performance, and trust, the successful candidate will demonstrate the following capabilities: Operating at pace and agile decision-making - using evidence and applying judgement to balance pace, rigour and risk. Committed to delivering high quality results, overcoming challenges, focusing on what matters, execution. Continuously looking for opportunities to learn, build skills and share learning. Sustaining energy and well-being Building strong relationships and collaboration, honest and open conversations. Budgeting and cost-consciousness *LI-GSK If you require an accommodation or other assistance to apply for a job at GSK, please contact the GSK Service Centre at 1-877-694-7547 (US Toll Free) or +1 801 567 5155 (outside US). GSK is an Equal Opportunity Employer and, in the US, we adhere to Affirmative Action principles. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, national origin, religion, sex, pregnancy, marital status, sexual orientation, gender identity/expression, age, disability, genetic information, military service, covered/protected veteran status or any other federal, state or local protected class. Important notice to Employment businesses/ Agencies GSK does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact GSK's commercial and general procurement/human resources department to obtain prior written authorization before referring any candidates to GSK. The obtaining of prior written authorization is a condition precedent to any agreement (verbal or written) between the employment business/ agency and GSK. In the absence of such written authorization being obtained any actions undertaken by the employment business/agency shall be deemed to have been performed without the consent or contractual agreement of GSK. GSK shall therefore not be liable for any fees arising from such actions or any fees arising from any referrals by employment businesses/agencies in respect of the vacancies posted on this site. Please note that if you are a US Licensed Healthcare Professional or Healthcare Professional as defined by the laws of the state issuing your license, GSK may be required to capture and report expenses GSK incurs, on your behalf, in the event you are afforded an interview for employment. This capture of applicable transfers of value is necessary to ensure GSK's compliance to all federal and state US Transparency requirements. For more information, please visit GSK's Transparency Reporting For the Record site.

Keywords: GlaxoSmithKline, Philadelphia , Scientific Leader, PBPK Modeling, Other , Collegeville, Pennsylvania

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