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Scientist in Neoantigen Screening

Company: Job Juncture
Location: Philadelphia
Posted on: December 5, 2019

Job Description:

Scientist Neoantigen Screening
My client is expanding and looking to hire a T-Cell Immunology Scientist for Neoantigen Screening.-- This person will play a key role with the ongoing development of a high throughput platform for screening T-cell receptors against neoantigen libraries.
The ideal candidate will take on the following tasks:


  • Establish an efficient neoantigen screening platform
  • Develop novel RNA, DNA and peptide-based technologies for HTS of T-cell receptors
  • Using multicolor flow cytometry, express recombinant proteins and enzymatic fluorophore labeling for applications
  • Collaborate with internal and external partners to identify and characterize oncology neoantigen libraries
  • Propose, validate and lead adoptive T-cell therapy programs for new therapeutic approaches

    --
    The ideal candidate will possess the following qualities:

    • PhD and strong background in molecular biology + assay development plus 2+ years of post-doc experience
    • Expert on molecular biology techniques, including DNA/RNA extractions, PCR, plasmid cloning, basic bioinformatics and vector construction, transfections, including retro and lentivirus production
    • Extensive tissue culture experience including cell line and primary culture techniques
    • Knowledge of bioinformatic software using algorithms to predict neoantigen binding such as NetMHCpan or pVACSeek
    • Experience with multi-color flow cytometry and data analysis
    • Track record of T cell functionality using surface expression markers, signaling, cytokine secretion, cell based killing or proliferation assays

Keywords: Job Juncture, Philadelphia , Scientist in Neoantigen Screening, Other , Philadelphia, Pennsylvania

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