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Senior Scientist, Translational Science Program Lead -Immunology

Company: Disability Solutions
Location: Spring House
Posted on: April 3, 2024

Job Description:

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at . Johnson and Johnson is recruiting for a Senior Scientist, Translational Sciences (TS), Immunology Translational Sciences and Medicine (TSM) to be located in Spring House, PA or Cambridge, MA. Remote work options may be considered on a case-by-case basis and if approved by the Company. At Johnson & Johnson, what matters most is helping people live full and healthy lives. We focus on treating, curing and preventing some of the most devastating and complex diseases of our time. And we pursue the most promising science, wherever it might be found. As Immunology Leaders, we know immunology is vital to human health. Driven by a relentless focus on patient unmet needs, we will redefine treatments for immune diseases by delivering transformational and accessible therapies and regimens to patients with immune-mediated disease. For more than two decades we have been a world leader in the development of transformational medicines, establishing one of the strongest, first-in-class portfolios and pipelines in the industry, including the first tumor necrosis factor (TNF) inhibitor, and first interleukin (IL)-12 and IL-23 inhibitors. We tirelessly push the boundaries of science and creativity, applying our deep disease insights, novel pathway science, new technologies, and treatment modalities to restore immune homeostasis. Translational Sciences and Medicine (TSM) is an integrated group of scientists composed of a clinical Translational Medicine (TM) team which conducts early clinical development and experimental medicine studies, and a Translational Sciences (TS) team which uses human based data and tissues to support the end to end portfolio. Together, the TSM group will provide the key learnings/insights on the next wave of novel therapies for these patients. Organizationally, TSM serves as a pivotal bridge between Discovery Research and the later phase Clinical Development group. TSM provides the necessary scientific and clinical expertise to advance an industry-leading pipeline of novel mechanism small molecules and biologic agents to address unmet need in immune-mediated diseases. TS has a broad remit stretching from support of discovery with human data to support target selection, through development of novel decision- making biomarkers for early phase clinical trials, target-centric indication sequencing and prioritization, and biomarker support of regulatory filings. It has expertise in biomarker development, disease biology research and in the application of immunology and data science technologies to support drug discovery and development. This position is within the Immunology Translational Sciences group and requires a highly motivated and skilled candidate to drive the translational research of innovative therapies across immune-mediated diseases. The Senior Scientist will provide biomarker support for Immunology clinical programs with a focus on maternal fetal immunology and rare diseases. The successful candidate will lead a matrixed team with diverse expertise in assay development and translational research. Activities include partnering with Discovery, biomarker, and clinical scientists to enable more informed early development decisions for portfolio programs through inclusion of novel and robust pharmacological endpoints in FIH trials. Furthermore, the candidate will partner with cross-functional teams to engage in interactions with external experts, commercial vendors, and academic institutions to advance Immunology portfolio. Responsibilities are as follows:

  • Drive operational efficiency for translational biomarker implementation, including engagement with external vendors and academic partners
  • Contribute to the strategies on molecular understanding of human diseases, patient stratification and biomarker-based endpoint translational strategies
  • Guide team members in high quality biomarker data generation and applying those results to making strategic decisions
  • Work closely with key leaders in partner functions to ensure project goals are met
  • Represent TS on program discovery and development teams
  • Contribute to the overall department's strategic direction with special focus on increasing the impact of translational science approaches in drug discovery and development
  • Lead internal and external collaborations to increase team capabilities or address a strategic need
  • Take initiative to identify, pilot and internalize emerging technical approaches that may drive increased value for portfolio execution
  • Help build an extensive external network of leaders in Immunology to enable strategic partnerships and awareness of advances in translational and biomarker research
  • Prepare and/or direct the preparation and review of protocols, clinical study reports and translational science sections of Translational plans, IBs, INDs, abstracts, manuscripts, and technical reports

Keywords: Disability Solutions, Philadelphia , Senior Scientist, Translational Science Program Lead -Immunology, Healthcare , Spring House, Pennsylvania

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