PhiladelphiaRecruiter Since 2001
the smart solution for Philadelphia jobs

Senior Scientific Director, Discovery PK/PD and Translational Pharmacometrics

Company: Johnson & Johnson
Location: Spring House
Posted on: October 19, 2020

Job Description:

Job Description Janssen Research & Development, L.L.C., a division of Johnson & Johnsons Family of Companies is recruiting for a Senior Scientific Director, Discovery PK/PD and Translational Pharmacometrics, located in Spring House, PA. At the Janssen Pharmaceutical Companies of Johnson & Johnson, we are working to create a world without disease. Transforming lives by finding new and better ways to prevent, intercept, treat and cure disease inspires us. We bring together the best minds and pursue the most promising science. We are Janssen. We collaborate with the world for the health of everyone in it. Learn more at www.janssen.com and follow us JanssenGlobal. Janssen Research & Development, LLC is part of the Janssen Pharmaceutical Companies. The Senior Scientific Director will sit on the leadership team of the department of Biologics Development Sciences (BDS) and report to its head, Vice President. BDS drives the discovery and development of biologic therapeutics as well as in-licensed or acquired assets pertaining to all of Janssen---s Therapeutic Areas, from early discovery through NME declaration. BDS is contributes to the preclinical development of monoclonal antibodies and novel biologic product formats such as bispecifics and T-cell redirectors, half-life extended peptides and proteins, gene therapy, oncolytic viruses, and CAR-T products. The Senior Scientific Director will lead the Discovery Translational Research group within BDS, providing strategic and scientific mentorship pertaining to biologics discovery and early development to a team of about 15 scientists (various levels) to successfully provide deliverables of translational pharmacology and model-guided drug design, working in close collaboration with other discovery and development leaders at Janssen. Having 4 direct reports and 11 or more indirect reports, to the Senior Scientific Director will also be responsible for operational team management and talent development. Scope of responsibility includes contributing to drug molecule design through reverse translation and modeling approaches, review and approval of data analyses from discovery studies, preclinical non-GLP studies, preclinical PK/PD and exploratory research, review and incorporation of relevant in vitro and ex vivo laboratory data from collaborators leading to systems biology, mechanistic and quantitative models for projecting first-in-human starting dose and efficacious dose range. He/she will also be expected to collaborate with key organizational partners (preclinical development PK/PD, nonclinical safety, clinical pharmacology, project management, etc) to drive the projection of human therapeutic window, enabling successful first-in-human studies and informing our discovery pipeline. The Senior Scientific Director will be responsible for the preparation and review/approval of discovery relevant sections of regulatory documents submitted to regulatory authorities, and impactful manuscripts for publication. Essential Functions: Provide intellectual and strategic input into large molecule drug discovery and early development, including but not limited to, study design and data analysis plans, preclinical and first-in-human (FIH) study protocols, bioanalytical strategies, and reports. Responsible for the scientific leadership in the conduct of pharmacokinetic (PK) and pharmacodynamic (PD) analyses and interpretation of data derived from preclinical studies, including in vitro and ex vivo experiments, toxicokinetic studies, and efficacy studies Responsible for the reverse translation from clinical studies and literature to improve preclinical knowledge and pharmacometric models to inform the discovery of new molecules, with utmost attention on evidence-based rational drug development Responsible for crafting necessary experimental studies to predict starting dose and efficacious dose in FIH studies, and collaborate with nonclinical safety colleagues to estimate/extrapolate the therapeutic window Perform and guide team members on external due diligence assignments Training and mentoring staff on effective presentations and reaching drug development outcomes successfully Communicate effectively with the project teams and stakeholder leadership within Janssen R&D, and with different line functions within BDS Evaluate and prioritize projects effectively, through delegation and resource allocation, to accomplish departmental and company objectives Serve as a JBIO representative on one therapeutic area related Discovery Portfolio Committee (DPC). Responsible for the preparation of the preclinical pharmacology section of regulatory submission documents Expertise in modeling software including NONMEM, Monolix, Matlab, and R Qualifications Requirements Education: Ph.D or Pharm D., with 12 years business experience in the pharmaceutical/biotechnology industry, and 3-5 years of experience performing progressively advanced duties at the director, or equivalent, level Proven track record in leading a scientific team(s) and direct and/or indirect people management experience; Strong collaborative skills and ability to influence Possesses a leadership position in a scientific discipline (or disciplines) as recognized externally as an expert in the preclinical or clinical pharmacometrics area. Published expertise with quantitative systems pharmacology highly preferred.

Keywords: Johnson & Johnson, Philadelphia , Senior Scientific Director, Discovery PK/PD and Translational Pharmacometrics, Executive , Spring House, Pennsylvania

Click here to apply!

Didn't find what you're looking for? Search again!

I'm looking for
in category
within


Other Executive Jobs


Director of Sales Strategy and Development
Description: Director of Sales Strategy and Development Description Alba Wheels Up is one of the most prominent Customhouse Brokers and Freight Forwarders in the United States. Our knowledge has set the standard with (more...)
Company: Alba Wheels Up Int'l
Location: Valley Stream
Posted on: 10/28/2020

Digital & Social Media Analytics Manager
Description: Title: Digital Social Media Analytics Manager Duration: 6 months could go perm Location: New York City, NY Responsibilities: Perform hands-on analyses on large volumes of ad serving platforms, individual (more...)
Company: Two95 International Inc.
Location: New York
Posted on: 10/28/2020

Director, Securities, Commodities and Derivatives - Economic Consulting
Description: About Economic and Financial Consulting at FTI ConsultingFTI is a global business advisory firm with a network of 5,700 employees in 28 countries. Our services are organized into five business segments: (more...)
Company: FTI Consulting
Location: New York
Posted on: 10/28/2020


In House Counsel Jobs New York - JDHuntr 34872 Senior Vice President and General Counsel, Washington
Description: In House Counsel Jobs New York - JDHuntr 34872 Senior Vice President and General Counsel, Washington, DC To apply go to JDHuntr.com Reporting
Company: JDHuntr In-House Counsel Jobs
Location: Columbia
Posted on: 10/28/2020

Commercial Insurance Account Manager - Small / Mid Markets
Description: THE COMPANY: Regional brokerage / insurance agency looking for an experienced commercial account manager.They provide a full range of insurance coverage and benefits programs offered by more
Company: Affinity Executive Search
Location: Great Neck
Posted on: 10/28/2020

Project Manager, IT Operations
Description: Job ID: 2 of Openings: 1Category: Information TechnologyCity: PurchaseState: NYCompany: Atlas Air, IncOverview br br Provide comprehensive project management skills, demonstrate innovative leadership, (more...)
Company: Atlas Air, Inc
Location: New York
Posted on: 10/28/2020

Infantryman - Management Training
Description: The Infantry is the backbone of the Army. These Soldiers fill the literal boots on the ground who are responsible for taking or holding ground during any combat operation. You'll attack, repel, and capture (more...)
Company: Army National Guard
Location: New York
Posted on: 10/28/2020

Cargo Operations Manager
Description: To lead, plan and manage all operational activities associated with cargo service handling in line with our procedures, policies and brand values. Job Responsibilities Full responsibility for delivering (more...)
Company: Swissport
Location: Weehawken
Posted on: 10/28/2020

Sr Manager, Software Engineering (United Income)
Description: McLean 2 19052 , United States of America, McLean, Virginia Sr Manager, Software Engineering United Income United Income is a recently acquired fin-tech startup looking to add a talented engineering (more...)
Company: Capital One
Location: Glenwood
Posted on: 10/28/2020

Director of Sales Enablement
Description: JOB DESCRIPTION: br br Reporting to the Sr Director of Field Enablement, the Director of Sales Enablement will manage all aspects of field enablement for Cloudera Sales roles globally - Inside Sales, (more...)
Company: Cloudera, Inc.
Location: New York
Posted on: 10/28/2020

Log In or Create An Account

Get the latest Pennsylvania jobs by following @recnetPA on Twitter!

Philadelphia RSS job feeds